Scott J Hultgren Selected Research

Urinary Tract Infections (Urinary Tract Infection)

9/2020	High-resolution imaging reveals microbial biofilms on patient urinary catheters despite antibiotic administration.
1/2019	Mucosal infection rewires TNFɑ signaling dynamics to skew susceptibility to recurrence.
1/2019	Biphenyl Gal and GalNAc FmlH Lectin Antagonists of Uropathogenic E. coli (UPEC): Optimization through Iterative Rational Drug Design.
1/2019	Urinary tract colonization is enhanced by a plasmid that regulates uropathogenic Acinetobacter baumannii chromosomal genes.
1/2018	Manganese acquisition is essential for virulence of Enterococcus faecalis.
1/2018	Hydrogen Sulfide Sensing through Reactive Sulfur Species (RSS) and Nitroxyl (HNO) in Enterococcus faecalis.
1/2018	Structure-based discovery of glycomimetic FmlH ligands as inhibitors of bacterial adhesion during urinary tract infection.
10/2017	Catheterization alters bladder ecology to potentiate Staphylococcus aureus infection of the urinary tract.
1/2017	Host and bacterial proteases influence biofilm formation and virulence in a murine model of enterococcal catheter-associated urinary tract infection.
10/2016	Antivirulence C-Mannosides as Antibiotic-Sparing, Oral Therapeutics for Urinary Tract Infections.

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Scott J Hultgren Research Topics

Disease

50	Infections 09/2020 - 03/2002
40	Urinary Tract Infections (Urinary Tract Infection) 09/2020 - 05/2003
9	Bacterial Infections (Bacterial Infection) 01/2020 - 10/2003
9	Inflammation (Inflammations) 01/2019 - 08/2010
7	Cystitis 12/2018 - 07/2005
5	Bacteriuria 09/2020 - 12/2002
5	Persistent Infection 01/2020 - 08/2010
5	Endocarditis 01/2018 - 05/2013
4	Foreign Bodies (Foreign Body) 01/2013 - 10/2010
3	Pyelonephritis 01/2021 - 05/2003
3	Reinfection 10/2016 - 01/2009
2	Anaplastic Large-Cell Lymphoma (Ki 1 Lymphoma) 02/2019 - 01/2019
2	Parkinson Disease (Parkinson's Disease) 01/2018 - 02/2012
2	Disease Progression 03/2016 - 12/2013
1	Contracture 02/2019
1	Neoplasms (Cancer) 01/2019
1	Tuberculosis (Tuberculoses) 01/2019
1	T-Cell Lymphoma (Lymphoma, T Cell) 01/2019
1	Oncogene Addiction 01/2019
1	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2018
1	Otitis Media 01/2018
1	Diabetes Mellitus 07/2015
1	Pain (Aches) 06/2015
1	Hyperplasia 01/2015
1	Coinfection 10/2011

Drug/Important Bio-Agent (IBA)

21	Anti-Bacterial Agents (Antibiotics)IBA 01/2019 - 10/2003
10	Virulence Factors (Pathogenicity Factors)IBA 01/2019 - 01/2005
9	CytokinesIBA 04/2015 - 07/2005
7	Proteins (Proteins, Gene)FDA Link 01/2018 - 03/2004
6	MannosidesIBA 01/2021 - 04/2012
4	Fibrinogen (Factor I)FDA Link 01/2019 - 09/2014
4	VaccinesIBA 01/2019 - 09/2014
4	Amyloid (Amyloid Fibrils)IBA 01/2018 - 02/2002
4	Interleukin-6 (Interleukin 6)IBA 04/2015 - 07/2005
3	Mannose (D-Mannose)IBA 02/2016 - 01/2005
3	Pharmaceutical PreparationsIBA 02/2016 - 08/2010
3	Granulocyte Colony-Stimulating Factor (G-CSF)IBA 01/2015 - 12/2008
3	Dexamethasone (Maxidex)FDA LinkGeneric 11/2014 - 08/2010
2	Biological ProductsIBA 01/2021 - 09/2012
2	Peptide Hydrolases (Proteases)FDA Link 01/2017 - 05/2013
2	Antimicrobial PeptidesIBA 04/2015 - 01/2015
2	Fimbriae Proteins (Pilin)IBA 10/2013 - 01/2012
2	N-Acetylneuraminic Acid (Sialic Acid)IBA 12/2012 - 03/2010
2	LipopolysaccharidesIBA 12/2012 - 07/2005
2	Sulfamethoxazole Drug Combination Trimethoprim (Co-Trimoxazole)FDA LinkGeneric 11/2011 - 12/2002
2	Toll-Like Receptor 4IBA 12/2006 - 04/2003
1	Arginine (L-Arginine)FDA Link 01/2020
1	Fluorometholone (FML)FDA Link 01/2019
1	Coal (Coals)IBA 01/2019
1	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 01/2019
1	Sulfides (Thioethers)IBA 01/2018
1	alpha-SynucleinIBA 01/2018
1	MicronutrientsIBA 01/2018
1	LigandsIBA 01/2018
1	ManganeseIBA 01/2018
1	Amyloidogenic ProteinsIBA 01/2018
1	Carbapenems (Carbapenem Antibiotics)IBA 01/2017
1	Colistin (Coly-Mycin)FDA Link 01/2017
1	Cysteine Proteases (Cysteine Protease)IBA 01/2017
1	Immune Sera (Antisera)IBA 10/2016
1	Oxygen (Dioxygen)IBA 10/2016
1	UbiquinoneIBA 10/2016
1	Peptides (Polypeptides)IBA 01/2016
1	Advanced Glycation End ProductsIBA 07/2015
1	SugarsIBA 07/2015
1	AminesIBA 07/2015
1	CathelicidinsIBA 04/2015
1	Messenger RNA (mRNA)IBA 04/2015
1	AKB-4924IBA 04/2015
1	Nitric Oxide (Nitrogen Monoxide)FDA Link 04/2015
1	ChemokinesIBA 04/2015
1	Ciprofloxacin (Cipro)FDA LinkGeneric 03/2015
1	Hemolysin Proteins (Hemolysins)IBA 02/2015
1	Phenobarbital (Luminal)FDA Link 01/2015
1	Interleukin-1 (Interleukin 1)IBA 01/2015
1	2-hydroxypyridineIBA 12/2014
1	AmidesIBA 12/2014
1	Glucose (Dextrose)FDA LinkGeneric 12/2014
1	Cyclooxygenase 2 (Cyclooxygenase-2)IBA 11/2014
1	AntibodiesIBA 09/2014
1	Estrogens (Estrogen)FDA Link 06/2013
1	Estradiol (Delestrogen)FDA LinkGeneric 05/2013
1	SynucleinsIBA 02/2012
1	Biocompatible Materials (Biomaterials)IBA 02/2012
1	MetalsIBA 01/2012
1	Green Fluorescent ProteinsIBA 10/2011
1	Interleukin-9 (Interleukin 9)IBA 09/2011
1	Interleukin-10 (Interleukin 10)IBA 09/2011
1	Macrophage Inflammatory Proteins (Macrophage Inflammatory Protein 1)IBA 10/2010
1	InterleukinsIBA 10/2010

Therapy/Procedure

17	Catheters 09/2020 - 10/2010
15	Therapeutics 01/2021 - 11/2009
4	Breast Implants (Breast Implant) 01/2020 - 01/2019
3	Urinary Catheters 10/2016 - 02/2012
2	Antibiotic Prophylaxis 06/2015 - 03/2015
1	Immunomodulation 11/2014
1	Artificial Urinary Sphincter 02/2012
1	Stents 02/2012
1	Oral Administration 11/2011
1	Indwelling Catheters (Indwelling Catheter) 10/2010